学习异质治疗效果（HTE）是许多领域的重要问题。大多数现有方法都使用单个治疗组和单个结果指标来考虑设置。但是，在许多现实世界中，实验始终如一 - 例如，在互联网公司中，每天进行A/B测试，以衡量许多感兴趣的不同指标的潜在变化的影响。我们表明，即使一个分析师在一个实验中仅关心HTES来实现一个指标，也可以通过共同分析所有数据来利用交叉实验和交叉结果度量相关性来大大提高精度。我们在张量分解框架中对这个想法进行形式化，并提出了一个简单且可扩展的模型，我们称之为低级或LR-LR-LERNER。合成数据和实际数据的实验表明，LR-LEARNER可以比独立的HTE估计更精确。

In this paper, we propose a novel technique, namely INVALIDATOR, to automatically assess the correctness of APR-generated patches via semantic and syntactic reasoning. INVALIDATOR reasons about program semantic via program invariants while it also captures program syntax via language semantic learned from large code corpus using the pre-trained language model. Given a buggy program and the developer-patched program, INVALIDATOR infers likely invariants on both programs. Then, INVALIDATOR determines that a APR-generated patch overfits if: (1) it violates correct specifications or (2) maintains errors behaviors of the original buggy program. In case our approach fails to determine an overfitting patch based on invariants, INVALIDATOR utilizes a trained model from labeled patches to assess patch correctness based on program syntax. The benefit of INVALIDATOR is three-fold. First, INVALIDATOR is able to leverage both semantic and syntactic reasoning to enhance its discriminant capability. Second, INVALIDATOR does not require new test cases to be generated but instead only relies on the current test suite and uses invariant inference to generalize the behaviors of a program. Third, INVALIDATOR is fully automated. We have conducted our experiments on a dataset of 885 patches generated on real-world programs in Defects4J. Experiment results show that INVALIDATOR correctly classified 79% overfitting patches, accounting for 23% more overfitting patches being detected by the best baseline. INVALIDATOR also substantially outperforms the best baselines by 14% and 19% in terms of Accuracy and F-Measure, respectively.

Multi-document summarization (MDS) has traditionally been studied assuming a set of ground-truth topic-related input documents is provided. In practice, the input document set is unlikely to be available a priori and would need to be retrieved based on an information need, a setting we call open-domain MDS. We experiment with current state-of-the-art retrieval and summarization models on several popular MDS datasets extended to the open-domain setting. We find that existing summarizers suffer large reductions in performance when applied as-is to this more realistic task, though training summarizers with retrieved inputs can reduce their sensitivity retrieval errors. To further probe these findings, we conduct perturbation experiments on summarizer inputs to study the impact of different types of document retrieval errors. Based on our results, we provide practical guidelines to help facilitate a shift to open-domain MDS. We release our code and experimental results alongside all data or model artifacts created during our investigation.

The number of international benchmarking competitions is steadily increasing in various fields of machine learning (ML) research and practice. So far, however, little is known about the common practice as well as bottlenecks faced by the community in tackling the research questions posed. To shed light on the status quo of algorithm development in the specific field of biomedical imaging analysis, we designed an international survey that was issued to all participants of challenges conducted in conjunction with the IEEE ISBI 2021 and MICCAI 2021 conferences (80 competitions in total). The survey covered participants' expertise and working environments, their chosen strategies, as well as algorithm characteristics. A median of 72% challenge participants took part in the survey. According to our results, knowledge exchange was the primary incentive (70%) for participation, while the reception of prize money played only a minor role (16%). While a median of 80 working hours was spent on method development, a large portion of participants stated that they did not have enough time for method development (32%). 25% perceived the infrastructure to be a bottleneck. Overall, 94% of all solutions were deep learning-based. Of these, 84% were based on standard architectures. 43% of the respondents reported that the data samples (e.g., images) were too large to be processed at once. This was most commonly addressed by patch-based training (69%), downsampling (37%), and solving 3D analysis tasks as a series of 2D tasks. K-fold cross-validation on the training set was performed by only 37% of the participants and only 50% of the participants performed ensembling based on multiple identical models (61%) or heterogeneous models (39%). 48% of the respondents applied postprocessing steps.

Machine Learning (ML) approaches have been used to enhance the detection capabilities of Network Intrusion Detection Systems (NIDSs). Recent work has achieved near-perfect performance by following binary- and multi-class network anomaly detection tasks. Such systems depend on the availability of both (benign and malicious) network data classes during the training phase. However, attack data samples are often challenging to collect in most organisations due to security controls preventing the penetration of known malicious traffic to their networks. Therefore, this paper proposes a Deep One-Class (DOC) classifier for network intrusion detection by only training on benign network data samples. The novel one-class classification architecture consists of a histogram-based deep feed-forward classifier to extract useful network data features and use efficient outlier detection. The DOC classifier has been extensively evaluated using two benchmark NIDS datasets. The results demonstrate its superiority over current state-of-the-art one-class classifiers in terms of detection and false positive rates.

The automation of an increasingly large number of software engineering tasks is becoming possible thanks to Machine Learning (ML). One foundational building block in the application of ML to software artifacts is the representation of these artifacts (e.g., source code or executable code) into a form that is suitable for learning. Many studies have leveraged representation learning, delegating to ML itself the job of automatically devising suitable representations. Yet, in the context of Android problems, existing models are either limited to coarse-grained whole-app level (e.g., apk2vec) or conducted for one specific downstream task (e.g., smali2vec). Our work is part of a new line of research that investigates effective, task-agnostic, and fine-grained universal representations of bytecode to mitigate both of these two limitations. Such representations aim to capture information relevant to various low-level downstream tasks (e.g., at the class-level). We are inspired by the field of Natural Language Processing, where the problem of universal representation was addressed by building Universal Language Models, such as BERT, whose goal is to capture abstract semantic information about sentences, in a way that is reusable for a variety of tasks. We propose DexBERT, a BERT-like Language Model dedicated to representing chunks of DEX bytecode, the main binary format used in Android applications. We empirically assess whether DexBERT is able to model the DEX language and evaluate the suitability of our model in two distinct class-level software engineering tasks: Malicious Code Localization and Defect Prediction. We also experiment with strategies to deal with the problem of catering to apps having vastly different sizes, and we demonstrate one example of using our technique to investigate what information is relevant to a given task.

Polypharmacy, most often defined as the simultaneous consumption of five or more drugs at once, is a prevalent phenomenon in the older population. Some of these polypharmacies, deemed inappropriate, may be associated with adverse health outcomes such as death or hospitalization. Considering the combinatorial nature of the problem as well as the size of claims database and the cost to compute an exact association measure for a given drug combination, it is impossible to investigate every possible combination of drugs. Therefore, we propose to optimize the search for potentially inappropriate polypharmacies (PIPs). To this end, we propose the OptimNeuralTS strategy, based on Neural Thompson Sampling and differential evolution, to efficiently mine claims datasets and build a predictive model of the association between drug combinations and health outcomes. We benchmark our method using two datasets generated by an internally developed simulator of polypharmacy data containing 500 drugs and 100 000 distinct combinations. Empirically, our method can detect up to 33\% of PIPs while maintaining an average precision score of 99\% using 10 000 time steps.

Causal disentanglement seeks a representation of data involving latent variables that relate to one another via a causal model. A representation is identifiable if both the latent model and the transformation from latent to observed variables are unique. In this paper, we study observed variables that are a linear transformation of a linear latent causal model. Data from interventions are necessary for identifiability: if one latent variable is missing an intervention, we show that there exist distinct models that cannot be distinguished. Conversely, we show that a single intervention on each latent variable is sufficient for identifiability. Our proof uses a generalization of the RQ decomposition of a matrix that replaces the usual orthogonal and upper triangular conditions with analogues depending on a partial order on the rows of the matrix, with partial order determined by a latent causal model. We corroborate our theoretical results with a method for causal disentanglement that accurately recovers a latent causal model.

Large language models (LLMs) have been shown to be able to perform new tasks based on a few demonstrations or natural language instructions. While these capabilities have led to widespread adoption, most LLMs are developed by resource-rich organizations and are frequently kept from the public. As a step towards democratizing this powerful technology, we present BLOOM, a 176B-parameter open-access language model designed and built thanks to a collaboration of hundreds of researchers. BLOOM is a decoder-only Transformer language model that was trained on the ROOTS corpus, a dataset comprising hundreds of sources in 46 natural and 13 programming languages (59 in total). We find that BLOOM achieves competitive performance on a wide variety of benchmarks, with stronger results after undergoing multitask prompted finetuning. To facilitate future research and applications using LLMs, we publicly release our models and code under the Responsible AI License.

Recently, transformer networks have outperformed traditional deep neural networks in natural language processing and show a large potential in many computer vision tasks compared to convolutional backbones. In the original transformer, readout tokens are used as designated vectors for aggregating information from other tokens. However, the performance of using readout tokens in a vision transformer is limited. Therefore, we propose a novel fusion strategy to integrate radar data into a dense prediction transformer network by reassembling camera representations with radar representations. Instead of using readout tokens, radar representations contribute additional depth information to a monocular depth estimation model and improve performance. We further investigate different fusion approaches that are commonly used for integrating additional modality in a dense prediction transformer network. The experiments are conducted on the nuScenes dataset, which includes camera images, lidar, and radar data. The results show that our proposed method yields better performance than the commonly used fusion strategies and outperforms existing convolutional depth estimation models that fuse camera images and radar.